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Protein Hydrolysate And Carbohydrate Supplement Increases Protein Synthesis Even In The Fed State

There have been a number of studies now that have showed carbohydrate and protein supplementation augments protein synthesis after resistance exercise. However, almost all these studies assessed subjects after an overnight fast. It is not surprising that in this fasted state amino acids would be limiting and therefore primed to respond to dietary intake. It is unknown if a positive effect would be observed in the fed state when ample amino acids are present from previous meals. Researchers from the Netherlands performed a study to examine whether a protein and carbohydrate supplement enhanced protein synthesis after resistance exercise performed in the evening in the fed state. They had subjects consume water during one trial as a control and a protein carbohydrate supplement during the other trial. The supplement consisted of a casein hydrolysate and a 50/50 mixture of glucose and maltodextrin. The supplement was consumed every 15 min during exercise and 30 and 90 min after exercise. The results showed even in the fed state muscle protein synthesis was increased. This study had an additional feature in that protein synthesis measures were conducted while subjects were sleeping. Although supplementation increased protein synthesis during exercise, there was no additional benefit during the sleeping hours. This study advances our knowledge by showing that a protein and carbohydrate supplement increases protein synthesis in the fed state, which is good news for athletes who workout in the evening.

Beelen M, Tieland M, Gijsen AP, Vandereyt H, Kies AK, Kuipers H, Saris WH, Koopman R, van Loon LJ. Co-ingestion of carbohydrate and protein hydrolysate stimulates muscle protein synthesis during exercise in young men, with no further increase during subsequent overnight recovery. J Nutr. 2008 Nov;138(11):2198-204.