In recent years, a good bit of interest has developed surrounding the potential impact phosphatidic acid can have on anabolic signaling and muscle hypertrophy. Briefly, phosphatidic acid has been shown in a number of previous studies to favorably impact changes that result in an increase in the translation of muscle proteins.
A recent 2014 study published in
Nutrition and Metabolism
extended the results of these studies to provide one of the first glimpses into how phosphatidic acid can impact changes in resistance-training humans (Joy, Gundermann et al. 2014). The published study was divided into two parts whereby the first part exposed muscle cells to different combinations of precursors related to phosphatidic acid and found positive results while the second part had resistance-training subjects complete an 8 week resistance training program. During this phase, 28 college-aged study participants who had already been resistance training consumed in a double-blind fashion either 750 mg of phosphatidic acid or a placebo and had their strength and body composition determined. When supplemented with phosphatidic acid, study participants were reported to increase their lean body mass by 2.4%, muscle cross sectional area by 1.0 cm and leg press strength by over 50 kilograms when compared to placebo.
Joy, J. M., D. M. Gundermann, R. P. Lowery, R. Jager, S. A. McCleary, M. Purpura, M. D. Roberts, S. M. Wilson, T. A. Hornberger and J. M. Wilson (2014). "Phosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy." Nutr Metab (Lond) 11: 29.