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EGCG, The Major Polyphenol In Green Tea Extract, Enhances Compliance To A Weight Loss Program

A very large body of work has shown positive effects of green tea on a wide range of biological effects that improve health. Most research has focused on EGCG as the predominant polyphenol in green tea responsible for thermogenic, antioxidant and anticarcinogenic effects. Several reports have linked EGCG to thermogenesis and fat oxidation in humans through inhibition of catechol O-methyltransferase (COMT), the enzyme that breaks down norepinephrine. Other work has hinted at a possible mechanism by which EGCG decreases food intake and thus it is possible EGCG could enhance compliance to a diet program. Italian researchers studied a unique form of EGCG complexed to a phospholipid N-oleyl-ethanolamine (NOE) in order to make it more bioavailable. The preliminary results suggest better adherence to a dietary weight loss program as evidence by fewer drops after 2 months (6%) compared to placebo (27%). In addition feelings of fullness and satiety were significantly increased and feelings of hunger were significantly decreased in the ECGC group as compared to the placebo group. The EGCG group also had a decrease in depressive symptoms, severity of binge eating and a decrease in insulin resistance. These findings indicate that in addition to metabolic benefits, a novel EGCG-phospholipid supplement decreases the desire for food and food intake thus improving compliance with diet.

Rondanelli M, Opizzi A, Solerte SB, Trotti R, Klersy C, Cazzola R. Administration of a dietary supplement ( N-oleyl-phosphatidylethanolamine and epigallocatechin-3-gallate formula) enhances compliance with diet in healthy overweight subjects: a randomized controlled trial. Br J Nutr. 2008 Jul 1:1-8. [Epub ahead of print]