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Does Creatine Also Function as an Antioxidant?

Does Creatine Also Function as an Antioxidant?


CREATINE MONOHYDRATE HAS EARNED A PLACE IN THE SUPPLEMENT REGIMENS OF MOST BODYBUILDERS DUE TO ITS WELL-VALIDATED ROLE IN ENHANCING PERFORMANCE THROUGH STRENGTH SUPPORT. NOW RESEARCHERS ARE EXAMINING A POSSIBLE LINK TO ANTIOXIDANT ACTIVITY. A recent study was published in the June 2015 issue of Redox Report, a peer-reviewed journal devoted to oxidative stress that examined the impact of creatine supplementation for antioxidant properties (Deminice and Jordao 2015). The study required two groups of rats to exercise anaerobically and/or supplement their diet with creatine. A 28-day supplementation period was followed before all rats were required to complete an acute exercise protocol consisting of vertical jumps. In response to supplementation and the exercise, the animals were examined for the impact of markers of oxidative stress. Interestingly, the authors reported that creatine operated as an antioxidant in only selected muscles and the muscle with the greatest outcome (the calf) is known to be a primarily aerobic or slow-twitch muscle group. Consequently, the authors reported that creatine operated as an effective antioxidant in more aerobically trained muscle and also that levels of oxidative stress were inhibited when creatine was administered.

As a dietary supplement, creatine is the most researched and supported ingredient available today for performance enhancement. These recent results also provide additional evidence that creatine may be beneficial for other reasons that directly impact the health and function of the muscle cell itself.

Scientific Reference

Deminice, R., and A. A. Jordao. 2015. "Creatine supplementation decreases plasma lipid peroxidation markers and enhances anaerobic performance in rats."  Redox Rep. doi: 10.1179/1351000215Y.0000000020.