Recently, evidence published in Molecular and Cellular Endocrinology shows that creatine supplementation in combination with resistance training blunts serum myostatin levels greater than exercise alone.
is a powerful growth inhibitor that works by increasing catabolism in skeletal muscle. In this double-blinded placebo controlled study, volunteers weight trained for 8 weeks while taking a creatine supplement or a placebo. Creatine
or placebo was loaded for the first week at 0.3g/kg/day and maintained thereafter at 0.05g/kg/day. Periodically, throughout the training/supplementation period, strength, lean mass, and serum levels of myostatin and growth and differentiation factor-associated serum protein-1 (GASP-1, a myostatin regulator) were measured. As expected, the exercise + placebo condition decreased myostatin levels and increased GASP-1 at week 4 and 8. However, those who took creatine
had twice the reduction in myostatin levels at week 4 and 8 compared to those training with the placebo. In addition, training with
supplementation increased upper and lower body strength and lean body mass better than resistance training with placebo.
Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K. Effects of oral creatine and resistance training on serum myostatin and GASP-1.Mol Cell Endocrinol. 2010 Apr 12;317(1-2):25-30.