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CLA, or conjugated linoleic acid, has received a lot of attention among researchers because of its health-promoting effects in animal and human studies. Of interest, CLA has been shown in some studies to enhance weight and fat loss. Another benefit of CLA may be to enhance the immune system. A study in the Dec 2004 issue of the American Journal of Clinical Nutrition examined the effects of C LA supplementation on immune cell function in healthy men. In a randomized, double-blind, cross-over study, men consumed either 0.63, 1.26, or 2.52 g CLA per day for a period of 6 months. Each 6 mg supplementation period was separated by a 6 week washout period. All three levels of CLA supplementation increased immune cell function as assessed by a decrease in mitogen-induced T lymphocyte activation, which may be favorable in situations such as allergy and inflammatory disease.

Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Grimble RF, Williams CM, Calder PC, Yaqoob P. Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am J Clin Nutr. 2004 Dec;80(6):1626-33.