HGH UP Description and Supplement Facts
Hybrid Anabolic / Near Hormonal
HGH Up is predominately an
herbal formula designed to support testosterone and other bodybuilding
and fitness benefits. Its 3,500 mg blend is powered by Chlorophytum
borivilanium (also called Safed musli), which is a good source of
saponins, although protodioscin content, if any, is uncertain because it
is not specified. Also included is the key amino acid
L-carnitine L-tartrate as well as green tea extract and Mucuna
pruriens. This formula looks pretty solid but with closer
inspection this product would have garnered a higher rating if it had
contained a standardized potency protodioscin, like the
premium grade entries.
HGHup IS FORMULATED TO
•Growth hormone and local IGF-1
•Duration/viability of growth hormone pulse mass
•Androgen receptor structure, function, and
•Natural production of
MAIN MECHANISMS OF
Mucuna Pruriens, Vitamin B6 and L-Dopa: Support Growth Hormone
Output and Testosterone Production While Concurrently Decreasing
Somatostatin and Prolactin.
contains highly concentrated L-Dopa derived from Mucuna
Pruriens. Mucuna Pruriens is an Ayurvedic Herb that has both
anti-hypoglycemic and L-Dopa-increasing qualities. (32). L-Dopa has been
shown to significantly increase levels of growth hormone in human
subjects when administered orally. (1, 2, 3, 33).
• Oral viability in HGHUP critical for
product effectiveness, as growth hormone cannot be absorbed and is
rendered ineffective due to the fragility of the ingredients. Several
good examples are synthetic growth hormone (see Fig. 1) and growth
hormone releasing hormone (GHRH, see Fig. 2). These compounds
cannot be administered orally; because of their fragile amino acid
sequence is destroyed by stomach acids. This also holds true with the
vast majority of the so-called “GH Boosters” and “Peptides” commonly
found in sports nutrition products.
• L-Dopa and
Dopamine have also been shown to inhibit prolactin, a hormone that
suppresses male testosterone production. Prolactin also has a positive
correlation with a second hormone called somatostatin, which decreases
the both amount and effectiveness of circulating growth hormone.
Therefore, by lowering prolactin (and consequently somatostatin) levels,
HGHUP increases both testosterone and GH production; leading to greater
recovery and lean body mass (38, 39).
• Vitamin B6
is also included in the formula for HGHUP, as it can also help further
lower prolactin levels and increase the night-time peak of GH release
pulse, while at the same time increasing the rise in GH associated with
exercise by as much as 23% (7).
Huperzine-A: AChE Inhibition and
Mean serum GH by Decreasing Somatostatin
• Huperzine-A is a strong acetylcholine
esterase (AChE) inhibitor. Acetylcholine esterase inhibitors
have been shown in numerous scientific studies to inhibit somatostatin
via a variety of synergistic biomechanisms; all of which contribute to
increased levels of growth hormone (9, 10, 11, 12, 13, 14, 15, 16, 17,
• Somatostatin is a hormone that
exerts effects on anterior pituitary as well as pancreatic, liver and
gastrointestinal function (40, 41, 42, 43) .
• Somatostatin is of extreme
importance because it directly effects growth hormone release and is the
major regulating factor in slowing or even stopping growth hormone
• Therefore, by inhibiting
somatostatin, overall mean serum GH will increase (41,
•Somatostatin inhibits GH secretion indirectly via
antagonizing GHRH secretion (41, 42, 43).
Green Tea Extract, and (-)-epigallocatechin-3-O-gallate
(EGCG): Dopa Decarboxylase Inhibition and the
AChE-inhibiting Effects of HGHUP
the blood/brain barrier poorly, and cannot exert optimal effects on
target receptors unless enough of the compound reaches the
brain. L-Dopa is freely absorbed across this barrier, and when
L-dopa crosses the barrier readily, growth hormone levels
increase. (1-6, 32-33)
•L-Dopa is most
effective when conversion of L-Dopa to dopamine is mediated by a
decarboxylase inhibitor. A decarboxylase inhibitor is a
substrate that inhibits the metabolism of one biological entity into
another biological entity (2, 3, 4, 5, 19, 20,
•A decarboxylase inhibitor is generally
administered at the same time as L-Dopa / Mucuna in order to reduce
conversion of the L-dopa into dopamine in the periphery.
(-)-epigallocatechin-3-O-gallate (EGCG), which is found in high amounts
in the green tea extract used in HGHUP, is a potent decarboxylase
inhibitor. The decarboxylase-inhibiting qualities of EGCG have
been documented in several recent studies, in that EGCG seems to
prevent L-dopa from converting into dopamine; allowing more significant
levels of L-dopa to reach the brain and increase growth hormone levels
(1, 2, 3, 4, 5, 37).
•EGCG has also been shown to
significantly increase the effects of Huperzine A on acetylcholine
esterase inhibition by increasing the transport of Huperzine-A by serum
albumin. This allows for greater amounts of acetylcholine to
be present, therefore allowing for greater mean serum growth hormone.
Increased serum GH from HGHUP? allows for increased anabolism, better
recovery, and increased muscle mass (19,
SUPPORTS ANDROGEN RECEPTOR QUANTITY AND DENSITY AND FOR A BETTER BINDING
ENVIRONMENT FOR EXISTING
L-Carnitine-L-Tartrate and Magnesium:
Androgen Receptor Number and Density, and the Creation of a Better
• L-Carnitine L-Tartrate is an
amino acid that has been shown to increase the number of androgen
receptors in skeletal muscle, creating a better binding environment for
testosterone and other androgens by allowing for a greater number of
intact receptors available for hormonal interactions.
• Magnesium has been shown in more recent
studies to inhibit the binding of steroid hormone binding globulin
(SHBG) and free testosterone. SHBG binds free testosterone and
allows it to be excreted from the body, without binding the androgen
receptor. Magnesium keeps this from happening by altering the
binding affinity of testosterone to SHBG; thereby allowing for increased
amounts of free testosterone to remain active in the bloodstream.
• Other human research has shown that
supplemental magnesium, when taken along with other ingredients like
DHEA and Zinc, can significantly increase free testosterone. (25-27)
• Therefore, HGHUP allows for greater numbers of
androgen receptors and a better binding environment for testosterone in
skeletal muscle. This is a new breakthrough in sports supplementation as
HGHUP creates a better target for circulating free testosterone,
allowing for greater binding of testosterone to the extra receptors
which leads to increased protein synthesis, better recovery, and
increased muscle mass.
Benefits of HGH Up:
- Growth Hormone and IGF-1 Support
- Testosterone Booster
- Helps Facilitate Androgen Receptor Function
- Hormonal Enhancement
Mucuna Pruriens, Selenium, and Chlorophytum
Borivillanum Ethanolic/Sapogenic Extract: Testosterone
• Mucuna Pruriens has been shown in several
recent human studies to improve testosterone levels and spermatogenesis
in animal studies and humans, via prolactin inhibition. Prolactin, as
mentioned earlier, is a hormone that suppresses male testosterone
production (30-31, 34-36, 38-39).
• The ethanolic and
sapogenic extracts of Chlorophytum Borivaillanum have also been shown
in animal studies to increase testosterone, and anecdotal data from
products containing this compound also point to increased testosterone
and lean body mass for users of this phyto-androgenic compound. However,
the mechanism of action of Chlorophytum is poorly understood. (28-
1.Hanew, K., Tanaka, A, and Utsumi, A.
Plasma GH responses to GHRH, arginine, L-dopa, pyridostigmine,
sequential administration of GHRH and combined administration of PD and
GHRH in Turner’s syndrome. J. Endocrinol. Invest. 1998. Feb.; 21(2):
2.Schönberger W, Grimm W, Ziegler R. The effect of nacom
(L-dopa and L-carbidopa) on growth hormone secretion in 75 patients
with short stature. Eur J Pediatr. 1977 Dec
3.Schönberger W, Ziegler R, Brodt B, Grimm W.
HGH secretion after oral application of L-dopa and L-carbidopa. Eur J
Pediatr. 1976 Jun 8;122(3):195-200.
4.Fevang FO, Stoa RF,
Thorsen T, Aarskog D. The Effect of L-dopa with and without
decarboxylase inhibitor on growth hormone secretion in children with
short stature. Acta Paediatr Scand. 1977 Jan;
5.Philippi H, Pohlenz J, Grimm W, Koffler T,
Schönberger W. Simultaneous stimulation of growth hormone,
adrenocorticotropin, and cortisol with L-dopa, carbidopa, and
propranolol in children of short stature. Acta Paediatr, 2000
6.Gordon M, Markham J, Hartlein JM, Koller
JM, Loftin S, Black KJ. Intravenous levodopa administration in humans
based on a two-compartment kinetic model. J. Neurosci Methods, 2007 Jan
30:159(2):300-307. Epub 2006 Aug 24
suppresses the rise in prolactin and increases the rise in growth
hormone induced by exercise. 1982 Aug 12;307(7):444-5.
8.Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R,
Giovannini C Influence of administration of pyridoxine on circadian
rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal
subjects. Boll Soc Ital Biol Sper. 1984 Feb
9.Gordon RK, Haigh JR, Garcia GE, Feaster SR,
Riel MA, Lenz DE, Aisen PS, Doctor BP. Oral administration of
pyridostigmine bromide and huperzine A protects human whole blood
cholinesterases from ex vivo exposure to soman. Chem Biol Interact. 2005
Dec 15;157-158:239-46. Epub 2005 Oct 26.
10.Wang R, Yan H,
Tang XC. Progress in studies of huperzine A, a natural cholinesterase
inhibitor from Chinese herbal medicine. Acta Pharmacol Sin. 2006
11. Kelijman M, Frohman LA. The role of the
cholinergic pathway in growth hormone feedback. J Clin Endocrinol Metab.
12. Liang YQ, Tang XC. Comparative
studies of huperzine A, donepezil, and rivastigmine on brain
acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels
in freely-moving rats. Acta Pharmacol Sin. 2006
13. Giustina A, Bossoni S, Bodini C, Doga M,
Girelli A, Buffoli MG, Schettino M, Wehrenberg WB. The role of
cholinergic tone in modulating the growth hormone response to growth
hormone-releasing hormone in normal man. Metabolism. 1991
14.Friend K, Iranmanesh A, Login IS, Veldhuis
JD Pyridostigmine treatment selectively amplifies the mass of GH
secreted per burst without altering GH burst frequency, half-life, basal
GH secretion or the orderliness of GH release. Eur J Endocrinol. 1997
15.Dinan TG, O'Keane V, Thakore J.
Pyridostigmine induced growth hormone release in mania: focus on the
cholinergic/somatostatin system. Clin Endocrinol (Oxf). 1994
16. Thakore JH, Coffey I, Dinan TG. Time
dependency of pyridostigmine-induced growth hormone response. J Basic
Clin Physiol Pharmacol. 1994 Apr-Jun;5(2):117-2
17.Li YX, Zhang
RQ, Li CR, Jiang XH. Pharmacokinetics of huperzine A following oral
administration to human volunteers. Eur J Drug Metab Pharmacokinet. 2007
18.Haigh JR, Johnston SR, Peppernay A,
Mattern PJ, Garcia GE, Doctor BP, Gordon RK, Aisen PS. Protection of red
blood cell acetylcholinesterase by oral huperzine A against ex vivo
soman exposure: next generation prophylaxis and sequestering of
acetylcholinesterase over butyrylcholinesterase. Chem Biol Interact.
2008 Sep 25;175(1-3):380-6.
19. Xiao J, Chen X, Zhang L, Talbot
SG, Li GC, Xu M. Investigation of the mechanism of enhanced effect of
EGCG on huperzine A's inhibition of acetylcholinesterase activity in
rats by a multispectroscopic method. J Agric Food Chem. 2008
Feb. 13:56(3) 910-915.
20. Zhang L, Cao H, Wen J, Xu M. Green
tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory
effect of huperzine A on acetylcholinesterase by increasing the affinity
with serum albumin.
21. DI MARZIO L. (1) ; MORETTI S. (2) ;
D'ALO S. (1) ; ZAZZERONI F. (1) ; MARCELLINI S. (2) ; SMACCHIA C. (3) ;
ALESSE E. (1) ; CIFONE M. G. (1) ; DE SIMONE C. (1) ; Acetyl-l-carnitine
administration increases insulin-like growth factor 1 levels in
asymptomatic HIV-1-infected subjects : Correlation with its suppressive
effect on lymphocyte apoptosis and ceramide generation.
Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR,
French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson
DA, Deschenes MR, Maresh CM. Androgenic responses to resistance
exercise: effects of feeding and L-carnitine. Med Sci Sports Exer., 2006
Jul: 38(7): 1288-96.
23.Kraemer WJ, Volek JS, French DN, Rubin
MR, Sharman MJ, Gómez AL, Ratamess NA, Newton RU, Jemiolo B, Craig BW,
Häkkinen K. The effects of L-carnitine L-tartrate supplementation on
hormonal responses to resistance exercise and recovery. J Strength Cond.
Res. 2003 Aug: 17(3): 455-462,
24. André C, Berthelot A,
Robert JF, Thomassin M, Guillaume YC. Testimony of the correlation
between DHEA and bioavailable testosterone using a biochromatographic
concept: effect of two salts. J Pharm Biomed An., 2003 Dec 4: 33(5):
25. Excoffon L, Guillaume YC, Woronoff-Lemsi MC, André
C. Magnesium effect on testosterone-SHBG association studied by a novel
molecular chromatography approach. J Pharm Biomed An. 2009 Feb. 20:
26.Age-Related Eye Disease Study Research Group
(2001). “A Randomized, Placebo-Controlled, Clinical Trial of High-Dose
Supplementation With Vitamins C and E, Beta Carotene, and Zinc for
Age-Related Macular Degeneration and Vision Loss. Arch Opthalmology.
27. Berdanier, Carolyn D.; Dwyer, Johanna T.;
Feldman, Elaine B. (2007). Handbook of Nutrition and Food. Boca Raton,
Florida: CRC Press.
28.Thakur M. and Dixit V.K.* EFFECT OF
CHLOROPHYTUM BORIVILIANUM ON ANDROGENIC & SEXUAL BEHAVIOR OF
MALE RATS Indian Drugs 2006 April 43(4): 300-306
S.K., Safed Musli (Chlorophytum borivilianum) revisited, Journal of
Medicinal and Aromatic Plants. 2004, 26, 60-63.
30. Saxena S
and Dixit V.K: Role of total alkaloids of Mucuna pruriens Baker in
spermatogenesis in male rats, Indian Journal of Natural Products. 1987,
31. Unnithan A.R. and Tandon V.L: Role of growth
hormone in spermatogenesis in male rats. Indian Journal of Experimental
32. Modi KP, Patel NM, Goyal RK.
Estimation of L-dopa from Mucuna pruriens LINN and formulations
containing M. pruriens by HPTLC method Chem Pharm Bull (Tokyo). 2008
Mar: 56(3): 357-359.
33.Tharakan B, Dhanasekaran M, Mize-Berge
J, Manyam BV. Anti-Parkinson botanical Mucuna pruriens prevents levodopa
induced plasmid and genomic DNA damage.Phytother Res. 2007
34.Ahmad MK, Mahdi AA, Shukla KK, Islam N,
Jaiswar SP, Ahmad S.
Effect of Mucuna pruriens on semen profile
and biochemical parameters in seminal plasma of infertile men. Fertil
Steril. 2008 Sep;90(3):627-35. Epub 2007 Nov 14.
35. Shukla KK,
Mahdi AA, Ahmad MK, Shankhwar SN, Rajender S, Jaiswar SP. Mucuna
pruriens improves male fertility by its action on the
hypothalamus-pituitary-gonadal axis. Fertil Steril. 2008 Oct 28. [Epub
ahead of print]
36.Shukla KK, Mahdi AA, Ahmad MK, Jaiswar SP,
Shankwar SN, Tiwari SC .Mucuna pruriens Reduces Stress and Improves the
Quality of Semen in Infertile Men .Evid Based Complement Alternat Med.
2007 Dec 18. [Epub ahead of print
37.Bertoldi M, Gonsalvi M,
Voltattorni CB. Green Tea polyphenols: Novel irreversible inhibitors of
dopa decarboxylase Biochem Biophys Res Commun. 2001 Jun
38.Vaidya RA, Aloorkar SD, Sheth AR, Pandya SK.
Activity of bromoergocryptine, Mucuna pruriens and L-dopa in the control
of hyperprolactinaemia. Neurol India. 1978
39.Vaidya RA, Sheth AR, Aloorkar SD, Rege NR,
Bagadia VN, Devi PK, Shah LP. The inhibitory effect of the cowhage
plant- mucuna pruriens-and L-dopa on chloropromazine-induced
hyperprolactinemia. Neurol India. 1978 Dec;26(4):177-8.
Epelbaum J, Guillou JL, Gastambide F, Hoyer D, Duron E, Viollet
Somatostatin, Alzheimer's disease and cognition: An old story coming of
age? C. Prog Neurobiol. 2009 Jul 10.
41.Nikolaeva AA, Koroleva
SV, Ashmarin IP. [Research of interactions in the
dopamine-serotonin-somatostatin system promises new outlook in
fundamental and practical respects] Nikolaeva AA, Koroleva SV, Ashmarin
IP. Eksp Klin Farmakol. 2009 Mar-Apr;72(2):60-4. Review
Cordido F, Isidro ML, Nemiña R, Sangiao-Alvarellos S.Ghrelin and growth
hormone secretagogues, physiological and pharmacological aspect. Curr
Drug Discov Technol. 2009 Mar;6(1):34-42.
Blake AD. Function and expression of somatostatin receptors of the
endocrine pancreas. Mol Cell Endocrinol. 2008 May
44. Haff, G. Lecture Notes for Graduate
Study: Hormonal Parameters Relevant to Training. Appalachian State
45. Khoo, B. and Grossman, A.
Normal Physiology of the Hypothalamus and Anterior Pituitary. St.
Bartholomew’s Hospital, West Smithfield, London. Neuroendocrinology,
Hypothalamus, and Pituitary. 2007 Ch. 1 Lecture.
46.Various sources. Anecdotal Information concerning the usage
of AChE inhibitors with synthetic GH.
Nutriceuticals Research. Unpublished alpha testing for new
somatotropin-enhancing sports supplement. Charlotte, NC.
|HGH-UP - 150 caps |
|Serving Size: 5 Capsules|
Servings Per Container: 30
|Amount Per Serving||% Daily Value *|
|Somatotrophic-Myo nucleic Growth Factor 3500mg |
Chlorophytum Borivilanium (75% extract)
L-Tartrate Green Tea (98% Polyphenol 50% EGCG)
Mucuna Pruriens (standardized to 75% L-Dopa)
Magnesium (as Magnesium Carbonate)
Bioperine (95-98% Piperine Huperzine-A (Huperzia Serrata 5% Extract) Selenium
|Other Ingredients: Gelatin, Silica Dioxide, Candurin Silver Fine, FD&C Red #40, FD& C Blue #1, FD& C Yellow #5, FD& C Yellow #6.|
* Daily Values are based on a 2,000 calorie per day diet.
** Daily value not established.