Breakthrough New Pump Catalyst Radically
Outperforms Standard Arginine-Based Agents

Has any area of bodybuilding science advanced and evolved as rapidly as the pre-workout category? Ten years ago, pre-workout supplementation meant slugging down a bottle of sugary Gatorade. Five years ago, the first arginine-based NO potentiators arrived to great fanfare. And now, it looks like the science of pre-workout supplementation may have a new springboard with an entirely new kind of bodybuilding performance maximization catalyst found in Alpha Fury by BioQuest.
Before we take a closer look at this exciting new bodybuilding technology, it should be noted that if you're not incorporating a pre-workout product into your regimen, you're missing an opportunity to flood your muscles with key nutrients to help derive maximum benefit from each and every workout. From a physiological perspective, priming the pump before you hit the floor makes great sense. You supply a healthy dose of valuable nutrients right before stressful exercise and your body has at this invaluable fuel at its disposal to make the most of the training stimulus.  Add to the fact that blood flow increases several folds of magnitude from resting values after completing exercise and that delivery of these key ingredients will certainly be optimized.  Bigger muscles, great pumps, improved strength, and faster recovery are all suggested outcomes from this nutritional approach.

In the context of blood flow, a molecule called nitric oxide has stolen the show. The scientific interest centered upon nitric oxide is based upon a solid foundational physiological rationale. Nitric oxide stimulates relaxation and dilation of the blood vessels, resulting in a larger transport vehicle for valuable nutrients to travel to and from muscles resulting in an improved delivery as well as improved removal of unnecessary waste products.  In addition, nitric oxide is a key communicator between cells, almost an ambassador of sorts from one part of the body to another.

Much of the initial focus was centered on the conditionally essential amino acid, arginine, and a backbone molecule of a key energy system used by our cells during exercise called alpha-ketoglutarate.  Increased availability of these molecules as a result of supplementation is linked to increases in nitric oxide levels.  As a result, their combination was popularized and marketed for their ability to increase nitric oxide levels.  According to the theory, this increase in nitric oxide would stimulate vasodilation resulting in an increased transport capacity of the blood vessels, which would lead to greater adaptations to resistance training over time or improved strength, power and body composition.  In a subsequent study, Shelmadine and colleagues (Shelmadine and Cooke 2009) supplemented a combination of several ingredients including arginine, creatine and a host of other amino acids and reported improved resistance training adaptations. This combination of workout maximizing compounds (with minor tweaks across brands) is now well-established as the industry standard.

Enter Glyco-Carn, a patented form of glycine proprionyl-L-carnitine.  Glyco-Carn was developed by Sigma Tau Health Science, Inc. and has undergone fairly involved research investigation for its ability to mitigate nitric oxide production and influence various exercise outcomes.  In the last four years, a series of a studies completed by investigators have found that Glyco-Carn at a dosage of 4.5 grams over 4 weeks increased nitrate/nitrite levels (markers reflective of nitric oxide production) (Bloomer and Smith 2007) and in another study using the same 4.5 gram dose over 8 weeks of use, increased levels of nitric oxide (Bloomer and Tschume 2009) were observed.  Additionally, studies using Glyco-Carn found it to reduce the accumulation of lactate, a marker of fatigue, and increased the total amount of work completed after a series of cycling sprints (Jacobs and Goldstein 2009).  While actual levels of muscle carnitine aren't influenced by its use (Smith and Fry 2008), its use has also resulted in decreased levels of oxidative stress in the blood after supplementation and exercise, an important point which further supports its role at supporting exercise training (Bloomer and Farney 2010, Bloomer and Tschume 2009).  BioQuest, the makers of AlphaFury, have been closely monitoring this exciting line of investigation involving GlycoCarn, and are now among the manufacturers able to make this technology available to bodybuilders.

Another key ingredient included in the Alpha Fury formulation garnering recent interest in the literature is beta-alanine, a key molecule linked to improved exercise capacity and training volume.  Beta-alanine supplementation increases muscle carnosine content (Derave and Ozdemir 2007) which improves the muscle's ability to tolerate exercise stress (Artioli and Gualano 2010).  Thus, beta-alanine is most effective when training with multiple bouts of high-intensity exercise (like sprinting or lifting) or during exercise bouts longer than one minute (Artioli and Gualano 2010).  Small, multiple doses (~800 - 1,500 mg) are often used, but a four week study using a 4.8 gram dose improved muscle torque the most during later exercise bouts, an effect supportive of its ability to prolong exercise and lessen fatigue. In addition, a study using college football players found that 30 days of beta-alanine supplementation at a dosage of 4.5 grams increased the volume of completed exercise and decreased how challenging the workouts felt.  These positive results allowed for the subjects to perform more exercise, with less fatigue than before supplementing with beta-alanine (Hoffman and Ratamess 2008).

Alpha Fury's combination of Glyco-Carn and beta-alanine represents an exciting combination of ingredients in pre-workout supplementation science. These key ingredients are two primary players, which facilitate optimal exercise training and improved adaptations to your exercise program.  If your standard arginine-based pump complex has been letting you down lately, you owe it to yourself to check out what AlphaFury can do for you.

Artioli, G. G., Gualano, B., Smith, A., Stout, J., and Lancha, A. H., Jr. 2010. Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc 42: 1162-73.
Bloomer, R. J., Farney, T. M., Trepanowski, J. F., et al. 2010. Comparison of pre-workout nitric oxide stimulating dietary supplements on skeletal muscle oxygen saturation, blood nitrate/nitrite, lipid peroxidation, and upper body exercise performance in resistance trained men. J Int Soc Sports Nutr 7: 16.
Bloomer, R. J., Smith, W. A., and Fisher-Wellman, K. H. 2007. Glycine propionyl-l-carnitine increases plasma nitrate/nitrite in resistance trained men. J Int Soc Sports Nutr 4: 22.
Bloomer, R. J., Tschume, L. C., and Smith, W. A. 2009. Glycine propionyl-l-carnitine modulates lipid peroxidation and nitric oxide in human subjects. Int J Vitam Nutr Res 79: 131-41.
Derave, W., Ozdemir, M. S., Harris, R. C., et al. 2007. Beta-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters. J Appl Physiol 103: 1736-43.
Hoffman, J. R., Ratamess, N. A., Faigenbaum, A. D., et al. 2008. Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players. Nutr Res 28: 31-5.
Jacobs, P. L., Goldstein, E. R., Blackburn, W., Orem, I., and Hughes, J. J. 2009. Glycine propionyl-l-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr 6: 9.
Shelmadine, B., Cooke, M., Buford, T., et al. 2009. Effects of 28 days of resistance exercise and consuming a commercially available pre-workout supplement, no-shotgun(r), on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers in males. J Int Soc Sports Nutr 6: 16.
Smith, W. A., Fry, A. C., Tschume, L. C., and Bloomer, R. J. 2008. Effect of glycine propionyl-l-carnitine on aerobic and anaerobic exercise performance. Int J Sport Nutr Exerc Metab 18: 19-36.