Glucosamine and chondroitin
are normal constituents and important structural components of joint cartilage. Several studies had suggested they may be of value to people with knee pain from osteoarthritis. Osteoarthritis affects more than 20 million Americans and may double over the next 10 years. A very large multi-center study that involved over 1500 patients evaluating their efficacy and safety was just published in the
New England Journal of Medicine
. Compared to placebo, the combined treatment in patients with moderate-to-severe pain was 25% more effective, whereas the individual ingredients did not have a significant benefit beyond placebo. The findings from this very large study indicate that the combination of
(250 mg) and
(200 mg) was effective at reducing pain without side effects in people with moderate pain from osteoarthritis.
Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808.