Weight loss is often rapid during the early periods of dieting, but tends to slow down and eventually cease after several months for most people. One of the reasons for the reduced rate of weight loss is a sluggish metabolism. When dietary calories are reduced, the number of calories your body normally burns also decreases. Thus, you actually need less calories to maintain weight. This is why thermogenic weight loss supplements are so popular and effective; they function by stimulating resting metabolism and calorie burning. 7-Keto DHEA is a metabolite of dihydroepiandrosterone. Unlike DHEA, 7-Keto does not get converted into other steroids including estrogen and testosterone. Instead 7-Keto DHEA induces enzymes in the mitochondria of cells that increase thermogenesis. Two human studies showed promise for 7-Keto DHEA to augment weight loss. A recent study published in the Journal of Nutritional Biochemistry tested the effects of 7-Keto DHEA on resting metabolic rate in overweight subjects consuming a low calorie diet. For one week subjects consumed a diet that was restricted in energy by 800 kcal/day and were supplemented with either 7-Keto DHEA or placebo. As expected, the placebo trial caused metabolic rate to decrease by 75 kcal/day. The 7-Keto DHEA trial completely prevented the decline and actually increased resting metabolic rate by 21 kcal/day. The swing of almost 100 kcal per day may not seem like a lot, but over a month this would translate into one pound of fat loss without making any other changes I diet or exercise.

Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem. 2007 Apr 4; [Epub ahead of print]